原著論文(英文)
2012年

1.Wang W, Li Q, Takeuchi S, Yamada T, Koizumi H, Nakamura T, Matsumoto K, Mukaida N, Nishioka Y, Sone S, Nakagawa T, Uenaka T, Yano S.
Met Kinase Inhibitor E7050 Reverses Three Different Mechanisms of Hepatocyte Growth Factor-induced Tyrosine Kinase Inhibitor Resistance in EGFR Mutant Lung Cancer.
Clin Cancer Res 2012 Feb 8. [Epub ahead of print]

2011年

1. Yamada T, Takeuchi S, Kita K, Bando H, Nakamura T, Matsumoto K, Yano S.
Hepatocyte growth factor induces resistance to anti-epidermal growth factor receptor antibody in lung cancer.
J Thorac Oncol Nov 15. [Epub ahead of print].
2. Donev IS, Wang W, Yamada T, Li Q, Takeuchi S, Matsumoto K, Yamori T, Nishioka Y, Sone S, Yano S.
Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancer.
Clin Cancer Res 2011 17;2260-9.
3. Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev IS, Tacheuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S.
The EGFR ligands amphiregulin and heparin-binding EGF-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer.
Clin Cancer Res 2011;17:3619-30.
4. Li Q, Wang W, Yamada T, Matsumoto K, Bando Y, Uehara H, Nishioka Y, Sone S, Iwakiri S, Itoi K, Utsugi T, Yasumoto K,Yano S.
Pleural mesothelioma instigates tumor associated fibroblasts to promote progression via malignant cytokine network.
Am J Pathol 2011; 179:1483-93.
5. Yano S, Yamada T, Takeuchi S, Tachibana K, Minami Y, Yatabe Y, Mitsudomi T, Tanaka H, Kimura T, Kudoh S, Nokihara H, Ohe Y, Yokota J, Uramoto U, Yasumoto Y, Kiura K, Higashiyama M, Oda M, Saito H, Yoshida J, Kondoh K, Noguchi M.
Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort.
J Thorac Oncol 2011;6:2011-7.
6. Yamada T, Bando H, Takeuchi S, Kita K, Li Q, Wang W, Akinaga S, Nishioka Y, Sone S, Yano S.
Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2 expressing small cell lung cancer.
Cancer Sci 2011; 102:2157-63.
7. Tomimoto H, Hanibuchi M, Ogushi F, Okano Y, Shinohara T, Doi H, Yamamoto A, Takeuchi E, Yamamoto A, Azuma M, Tada H, Kanematsu T, Kakiuchi S, Goto H, Yano S, Nishioka Y, Sone S.
A multi-institutional phase II study of combination chemotherapy with S-1 plus cisplatin in patients with advanced non-small cell lung cancer. Oncology Letter in press.
8. Sano T, Takahashi M, Nozaki T, Takahashi Y, Tamura M, Nashimoto M.
Expanding the utility of heptamer-type sgRNA for TRUE gene silencing.
Biochem Biophys Res Commun 2011; 416:427-32.
9. Tanaka S, Nakada M, Hayashi Y, Nakada S, Kitamura-Sawada S, Furuyama N, Suzuki T, Kamide T, Hayashi Y, Yano S, Hamada JI.
Epithelioid glioblastoma changed to typical glioblastoma -the methylation status of MGMT promoter and 5-ALA fluorescence -.
Brain Tumor Pathol 2011;28:59-64.
10. Tanaka H, Kimura T, Kudoh S, Mitsuoka S, Watanabe T, Suzumura T, Tachibana K, Noguchi M, Yano S, Hirata K.
Reaction of plasma hepatocyte growth factor level in lung cancer patients treated with EGFR-TKIs.
Int J Cancer 2011 126:1410-6.
11. Shiirevnyamba A, Takahashi T, Shan H, Ogawa H, Yano S, Kanayama H, Izumi K, Uehara H.
Enhancement of osteoclastogenic activity in osteolytic prostate cancer cells by physical contact with osteoblasts.
Br J Cancer 2011;104:505-13.
12. Ogino H, Hanibuchi M, Kakiuchi S, Trung Van The, Goto H, Ikuta K, Yamada T, Uehara H, Tsuruoka A, Uenaka T, Wang W, Li Q, Takeuchi S, Yano S, Nishioka Y, Sone S.
E7080 suppresses hematogenous multiple organ metastases of lung cancer cells with nonmutated epidermal growth factor receptor.
Mol Cancer Ther 2011;10:1218-28.

2010年
1. Yamada T, Ohtsubo K, Izumi K, Takeuchi S, Mouri H, Yamashita K, Yasumoto K, Ghenev P, Kitagawa S, Yano S
Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage: a rare adverse effect of sunitinib
Int J Clin Oncol 2010. (in press)
2. Yamada T, Matsumoto K, Wang W, Li Q, NishiokaY, Sekido Y, Sone S, Yano S.
Hepatocyte growth factor reduces susceptibility to irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancer.
Clin Cancer Res 16:174-183, 2010.
3. Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, Hirao A, Yanagi S, Fukami K, Ishikawa Y, Sone S, Hara E, Ohtani N.
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
Cancer Res 70(22):9381-9390, 2010
4. Izumi K, Narimoto K, Sugimoto K, Kobori Y, Maeda Y, Mizokami A, Koh E, Yamada T, Yano S, Namiki M.
The Role of Percutaneous Needle Biopsy in Differentiation of Renal Tumors.
Jpn J Clin Oncol 40:1081-1086,2010
5. Okada G, Watanabe H, Ohtsubo K, Mouri H, Yamaguchi Y, Motoo Y, Sawabu N.
Multiple factors influencing the release of hTERT mRNA from pancreatic cancer cell lines during in vitro culture.
Cell Biol Int (in press).
6. Sakaguchi S, Goto H, Hanibuchi M, Otsuka S, Ogino H, Kakiuchi S, Uehara H, Yano S, Nishioka Y, Sone S.
Gender difference in bone metastasis of human small cell lung cancer, SBC-5 cells in natural killer-cell depleted severe combined immunodeficient mice.
Clin Exp Metastasis 27(5):351-359,2010
7. Kanematsu T, Hanibuchi M, Tomimoto H, Sakiyakma S, Kenzaki K, Kondo K, Bando H, Haku T, Yoneda K, Hirose T, Toyoda Y, Goto H, Sakaguchi S, Kinoshita K, Azuma M, Kakiuchi S, Kishi J, Azuma M, Tada H, Sumitomo M, Nishioka Y, Yano S, Sone S.
Epidemiological and clinical features of lung cancer patients from 1999 to 2009 in Tokushima Prefecture of Japan.
J Med Invest 57(3-4):326-333,2010.
8. Tanaka H, Kimura T, Kudoh S, Mitsuoka S, Watanabe T, Suzumura T, Tachibana K, Noguchi M, Yano S, Hirata K.
Reaction of plasma hepatocyte growth factor levels in non-small cell lung cancer patients treated with EGFR-TKIs.
Int J Cancer (in press)

（和文）
1.　山田忠明、毛利久継、泉浩二、竹内伸司、大坪公士郎、山下要、安本和生、北村星子、矢野聖二
Cisplatin+Vinorelbine併用化学療法が有効であった多発性肺転移を有する皮膚原発腺様嚢胞癌の1症例
癌と化学療法 8:1545-8,2010
2. 中川原寿俊、萱原正都、田島秀浩、北川裕久、太田哲生、全　陽、大坪公士郎.
早期胆道癌との鑑別が困難であった胆嚢dysplasiaの1例.　
胆道24(1) :135-138, 2010
3.東　勇気、北川裕久、牧野　勇、林　泰寛、中川原寿俊、田島秀浩、大西一朗、高村博之、谷　卓、萱原正都、太田哲生、大坪公士郎、毛利久継、蒲田敏文、松井　修、池田博子、浦出雅昭.
Osteoclast-like giant cellの発現がみられた若年性膵MCNの1例.　
肝胆膵画像12(6):782-786,2010

2009年
1.Wang W, Li Q, Yamada T, Matsumoto K, Matsumoto I, Oda M, Watanabe G, Kayano Y, Nishioka Y, Sone S, Yano S.
Crosstalk to stromal fibroblasts induces resistance of lung cancer to EGFR tyrosine kinase inhibitors.
Clinical Cancer Res 15:6630-6638, 2009.
2.Yamada T, Ohtsubo K, Mouri H, Yamashita K, Yasumoto K, Izumi K, Zen Y, Watanabe H, Yano S.
Combined chemotherapy with carboplatin plus irinotecan showed favorable efficacy in a patient with relapsed small cell carcinoma of the prostate complicated with meningeal carcinomatosis.
Int J Clin Oncol 14:468-472, 2009.
3.Ohtsubo K, Watanabe H, Tsuchiyama T, Mouri H, Yamaguchi Y, Motoo Y, Okai T, Sanada J, Matsui O, Kitamura T, Fujiki R, Tokuuye K, Sawabu N.
A case of advanced hepatocellular carcinoma treated effectively with irinotecan via hepatic arterial infusion followed by proton beam therapy.
J Infect Chemother 15:316-321, 2009.
4. Ohtsubo K, Watanabe H, Yamada T, Tsuchiyama T, Mouri H, Yamashita K, Yasumoto K, Ikeda H, Nakanuma Y, Yano S.
Cancer of unknown primary site in which tumor marker-oriented chemotherapy was effective and pancreatic cancer was finally confirmed at autopsy.
Intern Med 48:1651-1656, 2009.
5. Ikuta K, Yano S, Trung TV, Hanibuchi M, Goto H, Li Q, Wang W, Yamada T, Ogino H, Kakiuchi S, Uehara H, Sekido Y, Uenaka T, Nishioka Y, Sone S.
E7080, a multi-tyrosine kinase inhibitor, suppresses the progression of malignant pleural mesothelioma with different proangiogenic cytokine production profiles.
Clin Cancer Res15:7229-7237, 2009.
6. Yamada T, Muguruma H, Yano S, Ikuta K, Ogino H, Kakiuchi S, Hanibuchi M, Uehara H, Nishioka Y, Sone S.
Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in SCID mice.
Mol Cancer Ther 8:119-126, 2009.
7. Wang W, Nishioka Y, Ozaki S, Jalili A, Verma VK, Hanibuchi M, Abe S, Minakuchi K, Matsumoto T, Sone S.
HM1.24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody chimeric and humanized anti-HM1.24 antibodies mediate antibody-dependent cellular cytotoxicity against lung cancer cells.
Lung Cancer 63:23-31, 2009.

2008年
1. Wang W, Nishioka Y, Ozaki S, Jalili A, Abe S, Kakiuchi S, Kishuku M, Minakuchi K, Matsumoto T, Sone S.
HM1.24 (CD317) is a novel target against lung cancer for immunotherapy using anti-HM1.24 antibody.
Cancer Immunol Immunother 58(6):967-76. 2008
2. Kitagawa H, Ohta T, Makino I, Tani T, Tajima H, Nakagawara H, Ohnishi I, Takamura H, Kayahara M, Watanabe H, Gabata T, Matsui O, Zen Y.
Carcinomas of the ventral and dorsal pancreas exhibit different patterns of lymphatic spread.
Frontiers in Bioscience 13:2728-2735, 2008.
3. Ohtsubo K, Watanabe H, Okada G, Tsuchiyama T, Mouri H, Yamaguchi Y, Motoo Y, Okai T, Amaya K, Kitagawa H, Ohta T, Gabata T, Matsuda K, Ohta H, Sawabu N.
A case of pancreatic cancer with formation of a mass mimicking alcoholic or autoimmune pancreatitis in a young man. Possibility of diagnosis by hypermethylation of pure pancreatic juice.
JOP 9:37-45, 2008.
4.Ogino H, Yano S, Kakiuchi S, Muguruma H, Ikuta K, Uehara H, Tsuchida K, Sugino H, Sone S.
Follistatin suppresses the production of experimental multiple-organ metastasis by small cell lung cancer cells in NK cell-depleted SCID mice.
Clin Cancer Res 14:660-667, 2008.
5.Ogino H, Yano S, Kakiuchi S, Yamada T, Ikuta K, Nakataki E, Goto H, Nishioka Y, Ryan A, Sone S.
Novel dual targeting strategy with vandetanib induces tumor cell apoptosis and inhibits angiogenesis in malignant pleural mesothelioma cells expressing RET oncogenic rearrangement.
Cancer Letter 265:55-66, 2008.
6.Yamada T, Yano S, Ogino H, Ikuta K, Kakiuchi S, Hanibuchi M, Taniguchi, Sekido Y, Sone S.
Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2.
Cancer Sci 99:1603–1610, 2008.
7.Yano S, Wang W, Li Q,　Matsumoto　K, Sakurama　H, Nakamura T, Ogino　H, Kakiuchi　S, Hanibuchi　M, Nishioka　Y, Uehara　H, Mitsudomi T, Yatabe Y, Nakamura T, Sone S.
Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma cells with EGF receptor mutations.
Cancer Res 66:9479-9487, 2008.
8.Kitagawa H, Ohta T, Makino I, Tani T, Tajima H, Nakagawara H, Ohnishi I, Takamura H, Kayahara M, Watanabe H, Gabata T, Matsui O, Zen Y.
Carcinomas of the ventral and dorsal pancreas exhibit different patterns of lymphatic spread.
Frontiers in Bioscience 13, 2728-35, 2008.

2007年
1.Li Q, Yano S, Ogino H, Wang W, Uehara H, Nishioka Y, Sone S.
The therapeutic efficacy of anti-vascular endothelial growth factor antibody, bevacizumab, and pemetrexed against orthotopically implanted human pleural mesothelioma cells in SCID mice.
Clin Cancer Res 13:5918-25, 2007.
2.Tomimoto H,Yano S, Muguruma H, Kakiuchi S, Sone S.　
Levels of soluble vascular endothelial growth factor receptor 1 are elevated in the exudative pleural effusions.　
J Med Invest 54:146-53, 2007.
3.Tsuchiyama T, Nakamoto Y, Sakai Y, Marukawa Y, Kitahara M, Mukaida N, Kaneko S.
Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma.
J Immunol 178: 574-83, 2007.
4.Ohtsubo K, Watanabe H, Tsuchiyama T, Mouri H, Yamaguchi Y, Motoo Y, Ohnishi I, Gabata T, Sawabu N.
A case of autoimmune pancreatitis associated with retroperitoneal fibrosis.
J Pancreas 8: 320-5, 2007.
5.Koizumi K, Yasumoto K, et al.
Chemokine receptors expressed on cancer cells and chemokines derived from cancer cells: Their roles in cancer metastasis and progression.
Cancer Sci 98:1652-8, 2007.
6.Kitakata S, Yasumoto K, et al.
A case of primary small cell carcinoma of the breast.
Breast Cancer 14:414-7, 2007.
7.Yamashita K, Ougolkov AV, Nakazato H, Ito K, Ohashi Y, Kitakata H, Yasumoto K, Omote K, Mai M, Takahashi Y, Minamoto T.
Adjuvant immunochemotherapy with protein-bound polysaccharide K for colon cancer in relation to oncogenic beta-catenin activation.
Dis Colon Rectum 50:1169-81, 2007
8.Sone S,Yano S.
Molecular pathogenesis and its therapeutic modalities of lung cancer metastasis to bone.
Cancer Metastasis Rev 26:685-9, 2007.

原著論文(和文)

2008年
1. 毛利久継、土山智也、大坪公士郎、萱原正都、太田哲生、北川　諭など.
Octreotide投与下に5-FU少量持続静注を行い、著明なQOLの改善をみたperformance status不良の膵癌癌性腹膜炎の1剖検例.
日本消化器病学会雑誌 105:152-35, 2008.

2007年
1.大坪公士郎、渡邊弘之、土山智也、毛利久継、山口泰志、澤武紀雄.
シアノアクリレートを用いた予防的内視鏡的硬化療法が有用であった孤立性胃静脈瘤の4例.
Endoscopic Forum for digestive disease 23 : 19-24, 2007.